A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking
نویسندگان
چکیده
منابع مشابه
Imaging of receptor trafficking by using -bungarotoxin-binding-site-tagged receptors
-Amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors mediate excitatory synaptic transmission and are dynamically regulated during synaptic plasticity in the CNS. The membrane trafficking of AMPA receptors to synapses is critical for the regulation of the efficacy of excitatory synaptic transmission. Direct imaging of AMPA receptors in various cell compartments is important to diss...
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Shiga toxicosis is caused by retrograde trafficking of one of three types of Shiga toxin (STx), STx, STx1, or STx2. Trafficking depends on the toxin B subunits, which for STx and STx1 are identical and bind GPP130, a manganese (Mn)-sensitive intracellular trafficking receptor. Elevated Mn down-regulates GPP130, rendering STx/STx1 harmless. Its effectiveness against STx2, however, which is a ser...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2019
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2019.06.007